Not to be used with cargo marked "fragile."
Enemies grabbed with the Cargo Loader are disabled; they cannot move or use abilities. Grabbed enemies are held in front of your ship, right where the weapon ports are. They are disabled for an additional second when thrown, as they tumble helplessly. Feel free to open up with your best weapons at point-black range while your opponent can't fight back.
If you're caught in a Cargo Loader yourself, things become trickier. The Break Macro will get you out. A delayed-teleport ability like Telepotentiator can teleport you out, if the ability was in progress when you were grabbed. Persistence can help you recover from being thrown faster. Resonant Saw and Charged Caster Core will still work on their own even if you're being held. Certain passives like Security Shielding can make you less vulnerable while you're disabled.